Verdure Sciences' Boswellia Ingredient Receives USP Verification Published 2008 Medicine Alternative medicine review : a journal of clinical therapeutic Description Boswellia serrata (frankincense) is a moderate-to-large branching tree (growing to a height of 12 feet) found in India, Northern Africa, and the Middle East. Gupta I, Gupta V, Parihar A, Gupta S, Ldtke R, Safayhi H, Ammon HP. Wang R, Wang Y, Gao Z, Qu X. All Photos (1) 1076250. Green tea extract is a concentrated supplemental form of green tea. Get the latest business insights from Dun & Bradstreet. 1997;2(1):3743. Some studies have found that it may even be useful in treating certain cancers, such as leukemia and breast cancer. It protects various tissues including joints, connective tissue, liver, colon, and brain from pathologic changes, degeneration, and loss of function. The region covers an area of more than 31,813km2 (12,283sqmi). For industry information about COVID-19, visit our COVID-19 Disinfectants, sanitizers, cleaners and soaps section. Casperome, a lecithin-based formulation of Boswellia serrata extract representing the whole natural bouquet, has been developed and may have a role in the treatment of musculoskeletal disorders. Out of these four boswellic acids, acetyl-11-keto--boswellic acid (AKBA) is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation.1 Boswellia gum also contains the essential oils -thujene and p-cymene. 18 Phytomedicine. (2023). Boswellic acids in chronic inflammatory diseases. 3 Clin Pharmacokinet. The United States Pharmacopeial Convention, USP 3-Acetyl-11-keto--Boswellic Acid RS, https://doi.org/10.31003/USPNF_M867_04_01. 2-8C Pharmacopeia & Metrological Institute Standards It showed that the boswellia extract may be effective in treating Crohns disease. PDF Boswellia serrata Monograph - Natural Ingredient 23 Eur J Med Res. Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders. Natural Health Products Directorate's (NHPD) product licensing system allows applicants to reference the monographs below in support of the safety and efficacy of their product, rather than providing evidence for ingredients that are already known to be safe and efficacious when used under the conditions specified in the monographs. The concept of complementary and alternative medicine CAM and the role of specific plants and their anti-inflammatory activity in curing inflammatory painful diseases are described and herbal drugs can be a potential source to replace them. Mechanism of Action Many of the anti-inflammatory actions of Boswellia are credited to the tetra- and pentacyclic terpenoids called boswellic acids including -boswellic acid and the triterpene acids acetyl--boswellic acid, 11-keto--boswellic acid, and acetyl-11-keto--boswellic acid (also known as tircuallic, lupeolic, and roburic acids). At the time of submission of the application for orphan designation, clinical trials in patients with peritumoral oedema derived from brain tumours were ongoing.Boswellia serrata resin extract had not been marketed anywhere worldwide for peritumoral oedema derived from brain tumours or designated as orphan medicinal product elsewhere for this condition, at the time of submission. DOI: Soni KK, et al. 2018 Jan;32(1):140-150. doi: 10.1002/ptr.5963. For contact details of patients organisations whose activities are targeted at rare diseases, see: European Organisation for Rare Diseases (EURORDIS), a non-governmental alliance of patient organisations andindividuals active in the field of rare diseases. Let us know if you have suggestions to improve this article (requires login). Chopra A, et al. Created Date: 2011;8(7):61522. Therapy of active Crohns disease with Boswellia serrata extract H15 [Abstract]. 05.23.23 Ingredient supplier Verdure Sciences announced that its WokVel Boswellia serrata ingredient has passed USP's ingredient verification program, demonstrating that it meets the third-party certification's quality standards. Natural standard herb & supplement guide - e-book: An evidence-based reference. FOIA Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Guideline for assigning titles to USP dietary supplement monographs 20 Int J Colorectal Dis. (1999) 96,984; (2014 est.) (PDF) Boswellia: An evidence-based systematic review by the Natural labeled amount of Extract, calculated, on the dried basis, as the sum of Find company research, competitor information, contact details & financial data for WECOSTA of ROUBAIX, HAUTS DE FRANCE. EU/3/02/117 | European Medicines Agency Studies in rats show Boswellia protects colonic mucosa cells from acetic acid induced inflammation, and molecular investigations showed Boswellia to prevent tissue injury via increases in lipid peroxidation and nitric oxide, and the expression of inducible nitric-oxide synthase compared with untreated control animals.15. Maryland Heights, MO: Mosby. Hauts-de-France comprises five departments: Aisne, Nord, Oise, Pas-de-Calais, and Somme. Boswellia also called Indian Frankincense is an extract of the gummy oleoresin derived from beneath the bark of the Boswellia serrata tree, which is native to India, the Middle East and Northern Africa. Roubaix and Tourcoing, with their suburbs, have become part of the Lille urban agglomeration. 2012;130(9):217684. $245.00 Boswellia Serrata Extract (1 g) Catalog No: 1076250 CAS RN - Molecular Formula: N/A Product Type: Reference Standard Add to Cart star Add to Favorites Shipping Information Current Lot Information Current Lot: F1J024 CAS RN N/A Harmonized System (HS) Code *: 130219 UN No: N/A NDC No: N/A Molecular Formula: N/A Container Type: VIAL This sign is called peritumoral oedema. Resin made from boswellia extract has been used for centuries in Asian and African folk medicine. Boswellia Serrata Extract USP Reference Standard Sigma-Aldrich Tongkat ali is an herbal remedy suggested to treat various ailments, including low testosterone and male infertility. 2008;337:a2813. The Arthritis Foundation suggests 300400 mg three times per day of a product that contains 60 percent boswellic acids. No toxic reactions or significant side effects to Boswellia have been reported, and there are no known contraindications with diseases or conditions. The average dose of Boswellia is 300 milligrams (mg) three times a day. from Boswellia serrata. Acebo E, Ratn JA, Sauta S, Eizaguirre X, Trbol I, Prez JL. A 2001 study compared H15, a special boswellia extract, to the anti-inflammatory prescription drug mesalamine (Apriso, Asacol HD). Read more on this herbs effectiveness in stimulating. BOSWELLIA SERRATA - Uses, Side Effects, and More HHS Vulnerability Disclosure, Help Many of the anti-inflammatory actions of Boswellia are credited to the tetra- and pentacyclic terpenoids called boswellic acids including -boswellic acid and the triterpene acids acetyl--boswellic acid, 11-keto--boswellic acid, and acetyl-11-keto--boswellic acid (also known as tircuallic, lupeolic, and roburic acids). The resin is rich in triterpenic acids and has been used for centuries in traditional Ayurvedic medicine to treat inflammatory conditions. Standards Materials and Methods Figure 1. (2008). Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. Boswellia Serrata Extract. Prunes and prune juice have many health benefits, Should damiana be counted among the ranks of famed aphrodisiacs like oysters and asparagus? Oral therapy with the Boswellia extract or AKBA significantly reduces macroscopic and microcirculatory inflammatory features normally associated with indomethacin administration, indicating that the anti-inflammatory actions of the Bos Wellia extract in IBD may be due in part to boswellic acids such as AKBA. 2013;132(11):266781. Epub 2017 Dec 6. Glucocorticoids can be useful for long-term treatment, but can induce serious side effects. A brain tumour is a disease in which cells begin to grow in the tissues of the brain. Boswellia serrata, a potential antiinflammatory agent: an overview. Fresh foods and nutritional supplements are key. Boswellia extracts and isolated compounds in the oleoresin (the boswellic acids) have been scientifically investigated for >50 years for their analgesic and anti-inflammatory effects. Boswellia serrata. Boswellia serrata and Ocimum sanctum extracts reduce inflammation in an ova-induced asthma model of BALB/c mice. Hartmann RM, Fillmann HS, Martins MI, Meurer L, Marroni NP. According to the information provided by the sponsor, peritumoral oedema derived from brain tumours was considered to affect about 55,000 patients in the European Union. boswellia serrata extract (BWSE), cesium chloride, chondroitin sulfate, chrysin, curcumin, D-ribose, deoxy-D- glucose, diindolylmethane, . Phytother Res. Studies show that boswellia may reduce inflammation and may be useful in treating the following conditions: Because boswellia is an effective anti-inflammatory, it can be an effective painkiller and may prevent the loss of cartilage. Health enthusiasts have long raved about the countless benefits of wheatgrass, and for good reason. An orphan designation is not a marketing authorisation. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012. (2010). Designated orphan medicinal products are still investigational products, which have been considered for designation on the basis of potential activity. The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice. A randomized controlled trial (RCT) reported topical application of Boswellia to improve psoriatic scales in 70% of subjects compared with 10% in the placebo group.12 Boswellia, boswellic acids or a combination are shown to reduce inflammation and protect the joints,7protect the colon in from progressive pathological changes in adenomatous polyps,8inhibit cancer metastases in animal models of colorectal cancer,11protect the brain after ischemic injury, and reduce reperfusion injury.10It also protects the liver13 and pancreatic islets14 in diabetic rats and the liver from granuloma formation as a result of schistosome infections.9Boswellia may improve the leukocyte infiltration and superficial ulcers typical of ulcerative colitis. 12 Clin Cosmet Investig Dermatol. 1076250 USP Boswellia Serrata Extract Write a review United States Pharmacopeia (USP) Reference Standard Pricing and availability is not currently available. Peritumoral oedema is life-threatening. Contact Dermatitis. (2011). (2015). Boswellia serrata Extract - USP (1998). [3] The Conseil d'tat approved Hauts-de-France as the name of the region on 28 September 2016, effective the following 30 September.[4][5]. 2010;7(6):36677. In animal models of diabetes, histological and chemical studies show Boswellia species act to inhibit lymphocyte infiltration into islets, apoptosis of periinsular cells, and shrinking of islet size. Hauts-de-France (French pronunciation: [o d fs] (); Picard: Heuts-d'Franche; lit. Due to the herbs anti-inflammatory properties, boswellia may be effective in treating inflammatory bowel diseases such as Crohns disease and ulcerative colitis (UC). Please note that we are currently modifying documents to reflect this change. Leukotrienes are molecules that have been identified as a cause of inflammation. The Natural Health Products Directorate (NHPD) has changed its name to the Natural and Non-prescription Health Products Directorate (NNHPD) subsequent to its recently expanded mandate to include the oversight of non-prescription and disinfectant drugs in addition to natural health products (NHPs). The region's interim name Nord-Pas-de-Calais-Picardie was a hyphenated placename, created by hyphenating the merged regions' namesNord-Pas-de-Calais and Picardiein alphabetical order. Last medically reviewed on November 9, 2017. Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, Dey D, Raychaudhuri SP. Boswellia Serrata Extract USP Reference Standard Sigma-Aldrich Boswellia is available as a resin, pill, or cream. USP. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. The qualitative and quantitative determination of boswellic acids (BAs) is important for their use in dietary supplements aimed No drugnutrientherb interactions have been reported or demonstrated. and transmitted securely. PMC Last edited on 25 February 2023, at 17:04, "Tlchargement du fichier d'ensemble des populations lgales en 2020", The National Institute of Statistics and Economic Studies, "La carte 13 rgions dfinitivement adopte", "La Rgion a vot et s'appelle dsormais Hauts-de-France", "Regional GDP per capita ranged from 30% to 263% of the EU average in 2018", https://en.wikipedia.org/w/index.php?title=Hauts-de-France&oldid=1141553375, This page was last edited on 25 February 2023, at 17:04. Quantification of six boswellic acids in crude extract & commercial herbal products available in the market. MeSH Four acids in boswellia resin contribute to the herbs anti-inflammatory properties. The gummy oleoresin exuded from injured bark is known as salai guggul that has been used in the traditional medicine of India to treat pain and inflammation, particularly arthritic conditions. Isolated and concentrated individual boswellic acids are generally dosed at 100 mg each day in divided doses. Boswellia products are generally rated on their concentration of boswellic acids. A 1998 study of the herbs effect on bronchial asthma found that people who took boswellia experienced decreased asthma symptoms and indicators. Problems have not been reported. Natural Health Products Directorate's ( NHPD) product licensing system allows applicants to reference the . Were just beginning to understand how the anti-inflammatory and immune-balancing effects of boswellia can improve the health of an inflamed bowel. Monograph Title BOSWELLIA SERRATA EXTRACT Errata Identifier 0ab892ce-d1b3-0c07-5cee-af0793a60e8e Line 1 of Tailing factor: Change . 1998;3(11):5114. Boswellia (Indian frankincense), an extract of the Boswellia serrata tree with a long history of religious, cultural, and medicinal use in Asia and Africa [22] [23] [24], has been shown to have . (2003). 11-keto--boswellic acid and 3-acetyl-11-keto--boswellic acid; it may contain suitable DEFINITION Boswellia serrata Extract is prepared from pulverized Boswellia serrata, using suitable solvents such as isopropanol, alcohol, methanol, hexanes, or mixtures of these solvents. A novel C(28)-hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A(2). Would you like email updates of new search results? Natural Standard. 06813. -Boswellic acid. WECOSTA Company Profile | ROUBAIX, HAUTS DE FRANCE, France 2014;21(6):84756. Boswellia Serrata Extract Write a review United States Pharmacopeia (USP) Reference Standard Pricing and availability is not currently available. The data show a definite role of gum resin of Boswellia serrata in the treatment of bronchial asthma and improvement of disease as evident by disappearance of physical symptoms and signs. The Compendium of Monographs can help speed the evaluation of the safety and efficacy of medicinal ingredients commonly used in natural health products. While every effort has been made to follow citation style rules, there may be some discrepancies. The city was occupied by the Germans in World War I and World War II. DOI: https://doi.org/10.31003/USPNF_M867_04_01, Doc ID: GUID-1532E7B8-50D4-4951-94C2-6F075ED3811A_4_en-US, 17 Int J Med Sci. A European satellite communications centre (Eurotlport) is in Roubaix. Additional traditional uses for Boswellia include pain and arthritis; diarrhea and dysentery; ulcerative colitis and Chrons disease; lung inflammation including bronchitis, asthma, chronic obstructive pulmonary diseases; and pneumonia and heart disease patients. Before The United States Pharmacopeial Convention, USP 3-Acetyl-11-keto--Boswellic Acid RS, https://doi.org/10.31003/USPNF_M2775_01_01. New industry developed in Roubaix, and many companies have their headquarters there. PDF 46688 Proposed Rules Federal Register open access Highlights Development of UPLC-PDA method followed by Tof-MS/MS analysis for secondary metabolites characterization. 8 weeks, compared with the group taking placebo.18 A similar study gave patients 250 mg of a proprietary Boswellia product, and they noted improvements in osteoarthritic pain as soon as 7 days after beginning therapy.19 Osteoarthritis investigations show Boswellia to reduce general inflammatory mediators as well as inhibit cartilage-degrading enzyme MMP-317, thus helping to protect cartilage in osteoarthritis patients.19, Boswellia has been shown to be a safe and effective therapy in ulcerative colitis, chronic colitis, experimental ileitis, Chrons disease, and all inflammatory bowel conditions. Buy Boswellia Serrata Extract RS, USP-1076250 - Direct from USP Research shows you can prevent, halt, and even reverse type 2 diabetes with proper diet and lifestyle. It contains NLT 90.0% and NMT 110.0% of If you want to ask a question or request information from EMA, please Send a question to the European Medicines Agency. Boswellia serrata has beneficial anti-inflammatory and antioxidant properties in a model of experimental colitis. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. The antioxidant capacity and anti-diabetic effect of Boswellia serrata triana and planch aqueous extract in fertile female diabetic rats and the possible effects on reproduction and histological changes in the liver and kidneys. This shows the herb could play an important role in treating bronchial asthma. Gerhardt H, et al. For the United Kingdom, as of 1 January 2021, European Union law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland / NI. Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice. Studies continue and the anti-cancer activity of boswellia is becoming better understood. The dosage may need to be higher for IBD. Rockville, MD: United States Pharmacopeia. Another study showed boswellic acids to be effective in suppressing the invasion of pancreatic cancer cells. 5 J Nat Prod. Properties grade pharmaceutical primary standard manufacturer/tradename USP application (s) pharmaceutical (small molecule) format neat storage temp. Burseraceae). Effects of gum resin of Boswellia serrata in patients with chronic colitis. Other possible side effects of boswellia include: Boswellia extract may also interact with medications, including ibuprofen, aspirin, and other non-steroidal anti-inflammatory drugs (NSAIDs). This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. 2006 Oct;72(12):1100-16. doi: 10.1055/s-2006-947227. Sengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, Sarma KV, Raychaudhuri SK, Raychaudhuri SP. Siddiqui MZ. OA knee pain decreased after 90 days with the boswellia product, compared to a lesser dosage and placebo. Boswellia serrata resin extract might be of potential significant benefit, as it might offer a better safety profile than glucocorticoids. A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis. Moussaieff A, Yu J, Zhu H, Gattoni-Celli S, Shohami E, Kindy MS. 11 Int J Cancer. 7 Phytomedicine. 2011;354(12):18997. It is situated on the Canal de Roubaix in the plain of Flanders near the Belgian frontier and is united in the north with Tourcoing. Please enable it to take advantage of the complete set of features! . A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Furthermore, 19 of the 20 patients ( compared to 6 of 10 in the control group) taking Boswellia improved in one or more of the measured outcomes, including stool properties, histopathology, and blood markers such as hemoglobin, serum iron, calcium, phosphorus, proteins, total leukocytes, and eosinophils.21 A similar study gave patients Boswellia at 350 mg three times per day for 6 weeks and reported 82% of Boswellia-treated patients went into remission, compared with 75% of sulfasalazine-treated patients.22, An RCT on asthma patients showed Boswellia at a dose of 300 mg three times per day improved dyspnea, rhonchi, number of asthma attacks, and spirometry readings in 70% of subjects compared with only 27% of controls receiving placebo.23. (Fam. Much of the early research on the mechanism of action of Boswellia focused on leukotriene suppression accomplished via lipoxygenase inhibition. View Price and Availability. DOI: Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, researchgate.net/publication/12466811_Randomized_double_blind_trial_of_an_Ayurvedic_plant_derived_formulation_for_treatment_of_rheumatoid_arthritis, arthritis.org/living-with-arthritis/treatments/natural/supplements-herbs/guide/indian-frankincense.php, The Top Health Benefits of Prunes and Prune Juice, Kerry Boyle D.Ac., M.S., L.Ac., Dipl. One 2003 study published in the journalPhytomedicine found that all 30 people with OA knee pain who received boswellia reported a decrease in knee pain. 2011 May;36(10):1330-3. Planta Med. Applications Products Services Support. Many types of proinflammatory processes are associated with an increase in leukotrienes that contributes to chemotaxis, chemokinesis, and the synthesis and release of superoxide radicals and the release of lysosomal enzymes by phagocytes. Boswellia: Benefits, Side Effects, Dosage, and Interactions It can accelerate menstrual flow and may induce miscarriage in pregnant women. A high pressure may result in compression of different parts of the brain, causing damage to the brain tissues, and symptoms. View of the White Cliffs of Dover, England, from Cap Gris Nez, France, The gross domestic product (GDP) of the region was 161.7 billion euros in 2018, accounting for 6.9% of French economic output. 2014;28(9):13928. They write new content and verify and edit content received from contributors. The population tripled to 25,000 in the first half of the 19th century and reached more than 122,000 before World War I. added substances. Disclaimer. This study shows that a gum resin preparation from Boswellia serrata could be effective in the treatment of chronic colitis with minimal side effects. Boswellia serrata extract for the treatment of collagenous colitis. 6 Biochem Pharmacol. With 6,009,976 inhabitants as of 1 January 2015 and a population density of 189 inhabitants per km2, it is the third most populous region in France and the second-most densely populated in metropolitan France after its southern neighbour le-de-France. Supplement Facts Active Ingredient (s): Boswellic acid Alternate Name (s): Indian frankincense, Boswellia serrata, Boswellic acid Legal Status: Legal in the United States and available over the counter. Studies have also found that boswellia may fight advanced breast cancer cells, and it may limit the spread of malignant leukemia and brain tumor cells. | Terms & Conditions, Association for the Advancement of Restorative Medicine, Register for Our Neurology Fellowship Program, The Spelman Report AARM Member Podcasts, Fundamentals of Naturopathic Endocrinology. Overview Boswellia serrata is a tree native to India, Africa, and the Arabian Peninsula. After a long struggle in the second half of the 18th century, it obtained the same privileges as Lille to manufacture all of the textiles that the English made. A monograph is a written description of particular elements on an identified topic. In formaldehyde and adjuvant arthritis, AESG produced prominent anti-arthritic activity but no significant effect was observed in cotton pellet-induced granuloma test and it inhibited inflammation induced increase in serum transaminase levels and leucocyte counts but lacked any analgesic or anti-pyretic effects. Liu M, Chen P, Bchele B, Dong S, Huang D, Ren C, Zhang Y, Hou X, Simmet T, Shen J. Monographs are now accessible via the Natural Health Products Ingredients Database. In patients suffering from ulcerative colitis grade II and III the effect of Boswellia serrata gum resin preparation (350 mg thrice daily for 6 weeks) on stool properties, histolopathology and scan microscopy of rectal biopsies, blood parameters including Hb, serum iron, calcium, phosphorus, proteins, total leukocytes and eosinophils was studied. Boswellia, also known as Indian frankincense, is an herbal extract taken from the Boswellia serrata tree.